Novera Melanotan I 10mg

Melanotan I (afamelanotide, NDP-α-MSH) is a synthetic linear tridecapeptide analog of alpha melanocyte stimulating hormone (α-MSH), widely studied in laboratory research for its ability to activate melanocortin receptor signaling – primarily through MC1R – to promote eumelanin synthesis and photoprotection. Structure activity relationship studies demonstrate that two key amino acid substitutions (norleucine at position 4 and D-phenylalanine at position 7) grant Melanotan I substantially greater potency and metabolic stability than native α melanocyte stimulating hormone, making it a valuable reference compound in melanocortin receptor pharmacology and pigmentation research.

For researchers asking where can I buy melanotan peptides of verified quality, FillerSupplies.com supplies Melanotan I under the Novera brand for research and laboratory use only. This peptide is intended exclusively for licensed professionals conducting in vitro, animal-model, or approved clinical investigations – it is not sold for human cosmetic or therapeutic self-administration.

General Information About Melanotan I

Melanotan I is a 13–amino acid linear peptide with the sequence Ac-Ser-Tyr-Ser-Nle⁴-Glu-His-D-Phe⁷-Arg-Trp-Gly-Lys-Pro-Val-NH₂. The core pharmacophore responsible for biological activity is the His-D-Phe-Arg-Trp (Phe Arg Trp Lys–adjacent) tetrapeptide motif retained from native α-MSH. Its molecular weight is approximately 1,645.84 g/mol, and the two structural modifications – methionine → norleucine (oxidation resistance) and L-Phe → D-Phe (protease resistance) – are what distinguish it from the endogenous hormone.

Mechanistically, Melanotan I functions as a melanocortin receptor agonist. Upon receptor activation at MC1R on melanocytes, it stimulates adenylate cyclase, elevating intracyclic AMP (cAMP) levels. This upregulates microphthalmia-associated transcription factor (MITF), which in turn increases expression of key melanogenic enzymes – especially tyrosinase – driving eumelanin production. While Melanotan I shows high affinity for MC1R, it is technically a non selective agonist with measurable receptor activity at multiple melanocortin receptor subtypes (MC1R MC3R MC4R MC5R), though essentially inactive at MC2R. In its FDA-approved implant formulation (Scenesse®, indicated for erythropoietic protoporphyria), the apparent plasma half-life is approximately 15 hours, with plasma concentrations falling below quantitation by day 10 post-implant.

It is important to contextualize Melanotan I alongside related peptides. Melanotan 2 is a synthetic cyclic heptapeptide analogue of α-MSH (CAS 121062-08-6, molecular weight 1024.20 g/mol) that was first synthesized in the 1990s. While both compounds derive from the melanocortin system, Melanotan II‘s cyclic lactam bridge structure makes it a non-selective melanocortin receptor agonist across multiple receptor subtypes MC1R MC3R MC4R and MC5R, producing broader effects including on sexual function, appetite regulation, and energy balance. Additionally, Melanotan 2 is soluble in water and dilute acetic acid and is supplied as a lyophilized powder for research purposes only – it is not approved for human or veterinary use. Native α-MSH, by contrast, has a very short plasma half-life (approximately 30 minutes) and lower potency, limiting its utility in research applications without chemical modification.

Melanotan I Use in the Research Setting

In laboratory research contexts, Melanotan I is typically supplied as a high purity lyophilized powder for reconstitution, intended for research and laboratory use only by qualified researchers.

Melanogenesis and Pigmentation Research

Research shows that Melanotan I significantly increases eumelanin content and tyrosinase activity in human melanocytes in a dose-dependent manner, with preferential stimulation of eumelanin over pheomelanin. In a Phase II clinical study involving 77 Caucasian subjects genotyped for MC1R variant alleles (including Val60Leu, Asp84Glu, Val92Met, Arg151Cys, and Arg160Trp), three 10-day courses of Melanotan I at 0.16 mg/kg/day produced a mean melanin density increase of approximately +0.73 units versus a decrease of approximately –0.30 units in the placebo group.

By comparison, Melanotan II (MT II) – the synthetic cyclic heptapeptide – activates subtypes MC1R MC3R MC4R and MC5R more broadly, producing not only melanin production effects but also off-target actions on sexual arousal, erectile dysfunction pathways, and appetite regulation via MC3R MC4R and MC5R. Reported side effects of Melanotan II include nausea and skin damage, and Melanotan II can cause severe health risks including melanoma. In the context of melanogenesis research, Melanotan I’s more focused MC1R profile makes it a preferred reference compound for isolating pigmentation-specific pathways within the melanocortin system.

Photoprotection Studies

Clinical research in erythropoietic protoporphyria (EPP) demonstrates that 16 mg subcutaneous implants of afamelanotide (Melanotan I) increased absolute skin melanin levels by approximately 28–29% compared to baseline when administered every 60 days. The implant releases more than 90% of the dose by day 5, yet the photoprotective effect persists for 40–60 days, diminishing around day 40–45 post-implant – a pharmacodynamic duration that substantially outlasts measurable plasma concentrations.

Research suggests this sustained photoprotection arises because increased eumelanin deposition in the epidermis continues to absorb and scatter UV radiation long after the peptide itself has been cleared. This is distinct from FDA-approved self-tanners, which function by staining only the outermost layer of skin without altering melanocyte biology.

The following table compares key properties relevant to photoprotection research:

Important to Know: Melanotan stimulates melanin production leading to increased risk of darkening moles. Outside approved clinical settings, case reports document rapid growth of pigmented lesions, and researchers should monitor nevi carefully in any model involving prolonged melanocortin receptor agonist exposure.

Receptor Selectivity Research

Melanotan I binds with high affinity to MC1R while showing substantially weaker activity at MC3R, MC4R, and MC5R, and essentially no activity at MC2R. This profile contrasts with Melanotan II, which is classified as a non-selective melanocortin receptor agonist with significant engagement across multiple receptor subtypes (MC1R MC3R MC4R MC5R). Binding affinity data from the literature places NDP-MSH analogues in the low nanomolar to sub-micromolar range for MC1R; related cyclic melanocortin analogues show IC₅₀ values of approximately 155 ± 16 nM, providing useful context for comparative melanocortin receptor pharmacology.

The broader receptor profile of Melanotan II explains its additional effects on sexual function, sexual arousal, and appetite regulation through MC4R – pathways not significantly activated by Melanotan I at research-relevant concentrations. Studies in the literature have also linked unregulated use of Melanotan II with rare but serious adverse events including renal infarction.

Important to Know: Despite its relative MC1R selectivity, Melanotan I is not entirely devoid of activity at other melanocortin receptor subtypes. Long-term safety data outside the approved EPP indication remain limited, and researchers should consider potential off-target effects when designing protocols. Products sold online may contain contaminants and unknown impurities, and health authorities advise against purchasing unregulated tanning products online. There are no legal stores selling Melanotan II for cosmetic tanning. Melanotan II is often sold in the gray market labeled as research chemicals.

Stability and Formulation Studies

As a linear peptide, Melanotan I is inherently less stable in circulation than cyclic analogs such as Melanotan 2 (MT 2). However, its D-Phe⁷ and Nle⁴ modifications confer meaningful resistance to proteolysis and oxidation, respectively – a key insight from decades of structure activity relationship studies in the melanocortin field.

“The minimal sequence required for the biological activity of α-MSH is His⁶-Phe⁷-Arg⁸-Trp⁹, and substitution by D-Phe and norleucine increases potency and stability over native α-MSH.”

In implant formulations (Scenesse®), more than 90% of the dose is released by day 5, with the implant matrix fully bioresorbed by approximately 60 days. For lyophilized powder used in laboratory research, proper storage requires refrigeration or freezing, protection from moisture and light, and reconstitution in sterile water or appropriate buffer immediately prior to use. These stability considerations are critical for researchers maintaining stock of Melanotan I for ongoing experimental protocols.

Buy Melanotan I Online at FillerSupplies.com

For qualified researchers and medical professionals seeking to discover a reliable source for Melanotan I, FillerSupplies.com offers this peptide under the Novera brand with the commitment to quality and service that researchers require. Whether you are investigating melanocortin receptor pharmacology, melanogenesis pathways, or photoprotection mechanisms, you can contact our team for pricing, bulk orders, and technical support.

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If you have been searching where can I buy melanotan 2 as well, note that Melanotan 2 is available for research purposes only through FillerSupplies.com – it is not approved for human or veterinary use. All peptides supplied by FillerSupplies.com are intended exclusively for research and laboratory use by qualified professionals.

Related research peptides available at FillerSupplies.com: PT-141.